Detalhe da pesquisa
1.
Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor.
Cell
; 172(3): 578-589.e17, 2018 01 25.
Artigo
Inglês
| MEDLINE | ID: mdl-29373830
2.
Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.
Nature
; 629(8011): 435-442, 2024 May.
Artigo
Inglês
| MEDLINE | ID: mdl-38658751
3.
Functional interplay between caspase cleavage and phosphorylation sculpts the apoptotic proteome.
Cell
; 150(2): 426-40, 2012 Jul 20.
Artigo
Inglês
| MEDLINE | ID: mdl-22817901
4.
Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine.
Nat Chem Biol
; 18(12): 1388-1398, 2022 12.
Artigo
Inglês
| MEDLINE | ID: mdl-36097295
5.
Author Correction: Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine.
Nat Chem Biol
; 18(11): 1288, 2022 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-36180594
6.
Pathophysiological significance and therapeutic targeting of germinal center kinase in diffuse large B-cell lymphoma.
Blood
; 128(2): 239-48, 2016 07 14.
Artigo
Inglês
| MEDLINE | ID: mdl-27151888
7.
Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach.
Blood
; 125(20): 3133-43, 2015 May 14.
Artigo
Inglês
| MEDLINE | ID: mdl-25833960
8.
Profiling protein kinases and other ATP binding proteins in Arabidopsis using Acyl-ATP probes.
Mol Cell Proteomics
; 12(9): 2481-96, 2013 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-23722185
9.
Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways.
Proc Natl Acad Sci U S A
; 108(12): 4834-9, 2011 Mar 22.
Artigo
Inglês
| MEDLINE | ID: mdl-21383145
10.
Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics.
J Biol Chem
; 287(13): 9742-9752, 2012 Mar 23.
Artigo
Inglês
| MEDLINE | ID: mdl-22223645
11.
Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.
Nat Chem Biol
; 7(4): 203-5, 2011 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-21378983
12.
Fragment-based covalent ligand discovery.
RSC Chem Biol
; 2(2): 354-367, 2021 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34458789
13.
Correction: Fragment-based covalent ligand discovery.
RSC Chem Biol
; 2(2): 670-671, 2021 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34459829
14.
Design and synthesis of AX4697, a bisindolylmaleimide exo-affinity probe that labels protein kinase C alpha and beta.
Bioorg Med Chem Lett
; 18(22): 5955-8, 2008 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-18774710
15.
Correction: Identification of a Tumor Specific, Active-Site Mutation in Casein Kinase 1α by Chemical Proteomics.
PLoS One
; 12(2): e0172649, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-28199383
16.
Identification of a Tumor Specific, Active-Site Mutation in Casein Kinase 1α by Chemical Proteomics.
PLoS One
; 11(3): e0152934, 2016.
Artigo
Inglês
| MEDLINE | ID: mdl-27031502
17.
Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State.
Cancer Discov
; 6(3): 316-29, 2016 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-26739882
18.
Global Human-Kinase Screening Identifies Therapeutic Host Targets against Influenza.
J Biomol Screen
; 19(6): 936-46, 2014 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-24464431
19.
Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR.
Cancer Res
; 73(8): 2574-86, 2013 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-23436801
20.
Chemoproteomic profiling identifies changes in DNA-PK as markers of early dengue virus infection.
ACS Chem Biol
; 7(12): 2019-26, 2012 Dec 21.
Artigo
Inglês
| MEDLINE | ID: mdl-22999307